| 中文名称 |
N-羟基-3-(3-苯基氨基磺酰基苯基)丙烯酰胺 |
| 英文名称 |
PXD101;PX105684;PXD-101;PXD 101;PX-105684;N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide;(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]acrylamide |
| CAS识别号 |
414864-00-9 |
| MDL识别号 |
Null,without related properties. |
| EC识别号 |
Null,without related properties. |
| Beilstein |
Null,without related properties. |
| 分子式 |
C15H14N2O4S |
| 分子量 |
318.35 |
| 分子结构图 |
 |
| 产品性状 |
Belinostat (PXD101)是一种新型的HDAC抑制剂，IC50为27 nM，对抵抗Cisplatin的肿瘤有效。 |
| 质量标准 |
Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM. Belinostat inhibits the growth of tumor cells (A2780, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852) with IC50 from 0.2-0.66 μM. PD101 shows low activity in A2780/cp70 and 2780AD cells. Belinostat inhibits bladder cancer cell growth, especially in 5637 cells, which shows accumulation of G0-G1 phase, decrease in S phase, and increase in G2-M phase. Belinostat also shows enhanced tubulin acetylation in ovarian cancer cell lines. A recent study shows that Belinostat activates protein kinase A in a TGF-β signaling-dependent mechanism and decreases survivin mRNA. |
| 储存条件 |
-20 °C 冷藏保存，Stored at -20 °C |
| 包装说明 |
Bellancom原装进口,正品保证,Bellancom Chemistry The original. |
| 购买建议 |
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