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中文名(CN) 英文名(EN) CAS No. 规格(SP) 报价(CNY) 产地(From) 类别(Key)
罗米地辛 Romidepsin,≥99% (FK228, Depsipeptide) 128517-07-7 1MG 1980.00 Bellancom-CN28732 标准品

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中文名称 罗米地辛, 一种有效的HDAC1和HDAC2抑制剂
英文名称 Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide;Cyclo[(2Z)-2-amino-2-buten
CAS识别号 128517-07-7
MDL识别号 Null,without related properties.
EC识别号 Null,without related properties.
Beilstein Null,without related properties.
分子式 C24H36N4O6S2
分子量 540.7
分子结构图 分子图
产品性状 经Bellancom Sciences独家专利技术精制而成,符合《中华人民共和国药典》、USP、EP、JP等相关质量标准。
质量标准 Romidepsin, a selective inhibitor of histone deacetylases (HDACs), was approved for the treatment of cutaneous T-cell lymphoma in November 2009 by the U.S. FDA. Romidepsin is a member of a new class of antineoplastic agents active in T-cell lymphoma, the histone deacetylase inhibitors. Romidepsin strongly down-regulated expression of the immunosuppressive cytokine, interleukin (IL)-10, frequently overexpressed in CTCL, at both the RNA and protein level in CTCL cell lines and at the RNA level in primary CTCL cells. Romidepsin also increased expression of IFNG RNA and decreased expression of IL-2 and IL-4 RNA, although to a lesser extent compared to IL-10. Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. Romidepsin promotes apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein.
储存条件 -20 °C 冷藏保存,Stored at -20 °C
包装说明 Bellancom原装进口,正品保证,Bellancom Chemistry The original.
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