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中文名(CN) 英文名(EN) CAS No. 规格(SP) 报价(CNY) 产地(From) 类别(Key)
CUDC-907,≥99% CUDC-907,≥99% 1339928-25-4 5MG 2150.00 Bellancom-CN28734 标准品

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中文名称 N-hydroxy-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxamide;N-hydroxy-2-(((2-(6-met
英文名称 CUDC-907,≥99%
CAS识别号 1339928-25-4
MDL识别号 Null,without related properties.
EC识别号 Null,without related properties.
Beilstein Null,without related properties.
分子式 C23H24N8O4S
分子量 508.55
分子结构图 分子图
产品性状 经Bellancom Sciences独家专利技术精制而成,符合《中华人民共和国药典》、USP、EP、JP等相关质量标准。
质量标准 Description: IC50 Value: 1.7/5.0/1.8/2.8 nM (HDAC1/2/3/10); 19/54/39 nM (PI3Kα/β/δ) [1] CUDC-907 potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes. in vitro: CUDC-907 induced the accumulation of acetylated histone H3, tubulin, and p53, as well as p21 expression in a dose-dependent manner (Supplementary Figs. S2-S5). Similarly, we observed that CUDC-907 inhibited the PI3K pathway, as indicated by the dose-dependent decreases in phosphorylation of AKT and its downstream targets, 4EBP-1 and p70S6, in H460 cells. CUDC-907 induced caspase-3 and -7 activation in HCT-116 colon cancer cells in a dose-dependent manner [1]. in vivo: oral administration of CUDC-907 inhibited growth of the Daudi cancer cell xenografts in a dose-dependent manner. Tumor stasis was observed at 100 mg/kg in this model without obvious toxicity. Furthermore, CUDC-907 caused tumor regression or stasis after intravenous (50 mg/kg) or oral administration (100 mg/kg) in a xenograft tumor model of SU-DHL4 diffuse large B-cell lymphoma (DLBCL) and caused tumor stasis in KRAS-mutant A549 NSCLC cell xenografts [1]. Toxicity: oral administration of CUDC-907 inhibited growth of the Daudi cancer cell xenografts in a dose-dependent manner. Tumor stasis was observed at 100 mg/kg in this model without obvious toxicity [1]. Clinical trial: Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-907 in Patients With Lymphoma or Multiple Myeloma. Phase 1
储存条件 -20 °C 冷藏保存,Stored at -20 °C
包装说明 Bellancom原装进口,正品保证,Bellancom Chemistry The original.
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