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中文名(CN) 英文名(EN) CAS No. 规格(SP) 报价(CNY) 产地(From) 类别(Key)
卡非佐米 Carfilzomib,≥99% 868540-17-4 5MG 1650.00 Bellancom-MP90504 通用试剂
卡非佐米 Carfilzomib,≥99% 868540-17-4 10MG 2860.00 Bellancom-MP90504 通用试剂
卡非佐米 Carfilzomib,≥99% 868540-17-4 50MG 8500.00 Bellancom-MP90504 通用试剂

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中文名称 Proteasomel抑制剂;卡非佐米; (alphaS)-alpha-[(4-吗啉基乙酰基)氨基]苯丁酰基-L-亮氨酰-N-[(1S)-3-甲基-1-[[(2R)-2-甲基环氧乙烷基]羰基]丁基]-L-苯丙氨酰胺
英文名称 (alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-phenylalaninamide
CAS识别号 868540-17-4
MDL识别号 Null,without related properties.
EC识别号 Null,without related properties.
Beilstein Null,without related properties.
分子式 C40H57N5O7
分子量 719.91
分子结构图 分子图
产品性状 Carfilzomib (PR-171)是一种不可逆proteasome抑制剂,IC50为<5 nM,在体外优先抑制β5亚基的ChT-L活性,对PGPH和T-L活性很弱或没有作用。
质量标准 Carfilzomib, an irreversible proteasome inhibitor, has a favorable safety profile and significant anti-tumor activity in patients with relapsed and refractory multiple myeloma (MM). Here we summarize the clinical pharmacokinetics (PK), metabolism, and drug-drug interaction (DDI) profile of carfilzomib. The PK of carfilzomib, infused over 2-10 min, was evaluated in patients with solid tumors or MM. The proteasome has emerged as an important target for cancer therapy with the approval of bortezomib, a first-in-class, reversible proteasome inhibitor, for relapsed/refractory multiple myeloma (MM). Carfilzomib induced a dose- and time-dependent inhibition of proliferation, ultimately leading to apoptosis. Carfilzomib showed increased efficacy compared with bortezomib and was active against bortezomib-resistant MM cell lines and samples from patients with clinical bortezomib resistance. Carfilzomib has entered in a Phase II clinical trial in the treatment of multiple myeloma
储存条件 -20 °C 冷藏保存,Stored at -20 °C
包装说明 Bellancom原装进口,正品保证,Bellancom Chemistry The original.
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