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中文名(CN) 英文名(EN) CAS No. 规格(SP) 报价(CNY) 产地(From) 类别(Key)
罗格列酮 Rosiglitazone (HPLC,≥98%) 122320-73-4 20MG 980.00 Sigma-R2408 通用试剂
罗格列酮 Rosiglitazone (HPLC,≥98%) 122320-73-4 50MG 1860.00 Sigma-R2408 通用试剂
罗格列酮 Rosiglitazone (HPLC,≥98%) 122320-73-4 100MG 3650.00 Sigma-R2408 通用试剂

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中文名称 罗格列酮
英文名称 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
CAS识别号 122320-73-4
MDL识别号 MFCD00871760
EC识别号 Null,without related properties.
Beilstein Null,without related properties.
分子式 C18H19N3O3S
分子量 357.43
分子结构图 分子图
产品性状 Rosiglitazone 是有效的降糖药,也是有效的噻唑烷二酮类胰岛素增敏剂,作用于大鼠,3T3-L1和人体脂肪细胞,IC50分别为12, 4和9 nM。
质量标准
用途: A potent and selective PPARγ agonist.
贮存: 储存温度 2-8°C
可溶性: Soluble in DMSO (72 mg/ml at 25 °C), methanol, water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and DMF (~25 mg/ml).
生化和生理学机理: Rosiglitazone is a potent, selective PPARγ (Peroxisome proliferator-activated receptor) agonist (Kd= 43 nM) which exhibits anti-diabetic and hepatotoxic effects. PPARγ belongs to a group of nuclear receptor proteins that are essential to the regulation of cellular differentiation, development and metabolism, and plays a functional role in adipogenesis. Studies also suggest that natural PPARγ agonists found in foods may be beneficial ant-inflammatory agents. Rosiglitazone, also known as BRL 49653, is a thiazolidinedione derivative effective in increasing insulin sensitivity in muscle and adipose tissue, as well as inducing adipocyte differentiation in pluripotent C3H10T1/2 stem cells
储存条件 2-8 °C 冷藏保存,Stored at 2-8 °C.
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